Women with severe morning sickness (hyperemesis gravidarum) in second trimester of pregnancy were found to be more likely to suffer placental complications.
Hyperemesis gravidarum occurs in 0.5-3% of pregnancies and is generally defined as severe illness or vomiting before 22 weeks gestation, usually requiring hospitalization for intravenous fluid. The condition is caused by high levels of human chorionic gonadotrophin (hCG), the pregnancy hormone, and a woman’s sensitivity to it.