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A four year trial found that the RTS,S/AS01E malaria vaccine was only 16.8% effective.

In highly variable results, vaccine efficacy declined over time — from 43.6% in the first year to almost zero in the fourth year — and with increasing exposure to malaria.

For every 100 vaccinated children, 65 cases of clinical malaria were averted. Multiple episodes of malaria were common, with 551 cases among 118 of the 223 children who received the vaccine.

A review of records for two million patients in Canada, the UK, and USA, found that high potency statins are associated with an increased risk of acute kidney injury.

High potency statin treatment was defined as at least 10mg rosuvastatin, at least 20mg atorvastatin, or at least 40mg simvastatin; all other statin treatments were defined as having low potency.

The BBC reports on an implantable blood testing device, presented at the DATE13 conference.

The prototype is 14mm long and can check on five different substances in the blood, including glucose and cholesterol. It is implanted under the skin and sends back data using Bluetooth. It is currently being tested on animals and it is hoped that it will be available to patients within four years.

There is growing evidence that adaptive immunity contributes to regeneration processes, for example bone fracture repair is modulated by T cells even in the absence of infection.

New research has shown a bone regeneration can be affected by T cells. Delayed fracture healing was associated with high levels of CD8+ T cells in peripheral blood.

Doctors have treated 5 patients with B cell acute lymphoblastic leukaemia (B-ALL) using T Cells genetically modified to target CD19, a protein found on the surface of B-cells.

Cytokine elevations directly correlated to tumor burden at the time of CAR-modified T cell infusions, with some patients requiring steroid therapy to ameliorate cytokine-mediated toxicities.

Further information is available from MSKCC on both the research results and the ongoing clinical trial.

The SERI Singapore Indian Eye Study study found that aspirin use was associated with early age-related macular degeneration in people with a history of cardiovascular disease, but not in those without.

SERI looked for signs of AMD in 3207 ethnic Indians aged 40 years or older living in Singapore. Aspirin intake overall was not associated with early AMD, but in those with a history of cardiovascular disease the association between aspirin intake and early AMD might warrant further investigation.

Previous research in Australia had found that regular use of aspirin was associated with and increased risk of AMD.