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A Japanese study shows that the immune system of women ages at a slower rate than that of men.

The age-related decline in the number of T cells and B cells, and in the proliferative capacity of T cells, was greater in men than in women.

There is growing evidence that adaptive immunity contributes to regeneration processes, for example bone fracture repair is modulated by T cells even in the absence of infection.

New research has shown a bone regeneration can be affected by T cells. Delayed fracture healing was associated with high levels of CD8+ T cells in peripheral blood.

Doctors have treated 5 patients with B cell acute lymphoblastic leukaemia (B-ALL) using T Cells genetically modified to target CD19, a protein found on the surface of B-cells.

Cytokine elevations directly correlated to tumor burden at the time of CAR-modified T cell infusions, with some patients requiring steroid therapy to ameliorate cytokine-mediated toxicities.

Further information is available from MSKCC on both the research results and the ongoing clinical trial.