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A retrospective cohort study of more than 46000 patients in a military health care system found that musculoskeletal conditions and pain are more common among statin users than among similar non-users.

The researchers warned that statins’ musculoskeletal adverse events may not be fully explored, especially in physically active individuals.

Statins are a class of drugs used to lower cholesterol levels by inhibiting an enzyme that plays a central role in the production of cholesterol in the liver.

A review of records for two million patients in Canada, the UK, and USA, found that high potency statins are associated with an increased risk of acute kidney injury.

High potency statin treatment was defined as at least 10mg rosuvastatin, at least 20mg atorvastatin, or at least 40mg simvastatin; all other statin treatments were defined as having low potency.